Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes. We examined whether HNF1A polymorphisms are associated with clinical outcomes in two independent cohorts combining 417 Eur...

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Bibliographic Details
Main Authors: Adrien Labriet, Elena De Mattia, Erika Cecchin, Éric Lévesque, Derek Jonker, Félix Couture, Angela Buonadonna, Mario D’Andrea, Lyne Villeneuve, Giuseppe Toffoli, Chantal Guillemette
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
metastatic colorectal cancer
hepatocyte nuclear factor 1-alpha
irinotecan
polymorphism
progression-free survival
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00712/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00712/full

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