Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration

Summary: Activation of the pro-degenerative protein SARM1 after diverse physical and disease-relevant injuries causes programmed axon degeneration. Original studies indicate that substantially decreased SARM1 levels are required for neuroprotection. However, we demonstrate, in Sarm1 haploinsufficien...

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Bibliographic Details
Main Authors: Stacey Anne Gould, Jonathan Gilley, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Michael Coleman
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Cell Reports
Subjects:
programmed axon degeneration
Wallerian degeneration
SARM1
NMNAT2
antisense oligonucleotides
therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721016028

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http://www.sciencedirect.com/science/article/pii/S2211124721016028

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