A double-edged sword role for ubiquitin-proteasome system in brain stem cardiovascular regulation during experimental brain death.

BACKGROUND: Brain stem cardiovascular regulatory dysfunction during brain death is underpinned by an upregulation of nitric oxide synthase II (NOS II) in rostral ventrolateral medulla (RVLM), the origin of a life-and-death signal detected from blood pressure of comatose patients that disappears befo...

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Bibliographic Details
Main Authors: Carol H Y Wu, Julie Y H Chan, Samuel H H Chan, Alice Y W Chang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3215722?pdf=render