The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells

Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensit...

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Bibliographic Details
Main Authors: Marc Hennequart, Christiaan F. Labuschagne, Mylène Tajan, Steven E. Pilley, Eric C. Cheung, Nathalie M. Legrave, Paul C. Driscoll, Karen H. Vousden
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26395-5