The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells
Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26395-5 |
| _version_ | 1818729289298739200 |
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| author | Marc Hennequart Christiaan F. Labuschagne Mylène Tajan Steven E. Pilley Eric C. Cheung Nathalie M. Legrave Paul C. Driscoll Karen H. Vousden |
| author_facet | Marc Hennequart Christiaan F. Labuschagne Mylène Tajan Steven E. Pilley Eric C. Cheung Nathalie M. Legrave Paul C. Driscoll Karen H. Vousden |
| author_sort | Marc Hennequart |
| collection | DOAJ |
| description | Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensitive to serine withdrawal. |
| first_indexed | 2024-12-17T22:43:31Z |
| format | Article |
| id | doaj.art-d92cf3d95d89487c9cc004996a158731 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T22:43:31Z |
| publishDate | 2021-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d92cf3d95d89487c9cc004996a1587312022-12-21T21:29:51ZengNature PortfolioNature Communications2041-17232021-10-0112111010.1038/s41467-021-26395-5The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cellsMarc Hennequart0Christiaan F. Labuschagne1Mylène Tajan2Steven E. Pilley3Eric C. Cheung4Nathalie M. Legrave5Paul C. Driscoll6Karen H. Vousden7The Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteThe Francis Crick InstituteCancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensitive to serine withdrawal.https://doi.org/10.1038/s41467-021-26395-5 |
| spellingShingle | Marc Hennequart Christiaan F. Labuschagne Mylène Tajan Steven E. Pilley Eric C. Cheung Nathalie M. Legrave Paul C. Driscoll Karen H. Vousden The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells Nature Communications |
| title | The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells |
| title_full | The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells |
| title_fullStr | The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells |
| title_full_unstemmed | The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells |
| title_short | The impact of physiological metabolite levels on serine uptake, synthesis and utilization in cancer cells |
| title_sort | impact of physiological metabolite levels on serine uptake synthesis and utilization in cancer cells |
| url | https://doi.org/10.1038/s41467-021-26395-5 |
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