Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021

Plasmodium falciparum pfhrp2 and pfhrp3 gene deletions among patients enrolled at 100 health facilities throughout Tanzania: February to July 2021

Abstract Plasmodium falciparum with the histidine rich protein 2 gene (pfhrp2) deleted from its genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The World Health Organization (WHO) recommends switching to a non-HRP2 RDT for P. falciparum clinical case diagnosis when pfhr...

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Bibliographic Details
Main Authors: Eric Rogier, Nastassia Battle, Catherine Bakari, Misago D. Seth, Douglas Nace, Camelia Herman, Achut Barakoti, Rashid A. Madebe, Celine I. Mandara, Beatus M. Lyimo, David J. Giesbrecht, Zachary R. Popkin-Hall, Filbert Francis, Daniel Mbwambo, Issa Garimo, Sijenunu Aaron, Abdallah Lusasi, Fabrizio Molteni, Ritha Njau, Jane A. Cunningham, Samwel Lazaro, Ally Mohamed, Jonathan J. Juliano, Jeffrey A. Bailey, Venkatachalam Udhayakumar, Deus S. Ishengoma
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Plasmodium falciparum
Tanzania
RDT
pfhrp2
pfhrp3
Gene deletion
Online Access:https://doi.org/10.1038/s41598-024-58455-3

Internet

https://doi.org/10.1038/s41598-024-58455-3

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