The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles

Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function. We investigated the effects of Apelin-13, pGlu1-apelin-13, Apelin-17, Apeli...

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Bibliographic Details
Main Authors: Yunlu Jiang, Maocai Yan, Chunmei Wang, Qinqin Wang, Xiaoyu Chen, Rumin Zhang, Lei Wan, Bingyuan Ji, Bo Dong, Huiyun Wang, Jing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
apelin
Elabela
arrestin
apelin receptor
biased signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.630548/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.630548/full

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