Studies towards the Design and Synthesis of Novel 1,5-Diaryl-1<i>H</i>-imidazole-4-carboxylic Acids and 1,5-Diaryl-1<i>H</i>-imidazole-4-carbohydrazides as Host LEDGF/p75 and HIV-1 Integrase Interaction Inhibitors

Studies towards the Design and Synthesis of Novel 1,5-Diaryl-1<i>H</i>-imidazole-4-carboxylic Acids and 1,5-Diaryl-1<i>H</i>-imidazole-4-carbohydrazides as Host LEDGF/p75 and HIV-1 Integrase Interaction Inhibitors

Two targeted sets of novel 1,5-diaryl-1<i>H</i>-imidazole-4-carboxylic acids <b>10</b> and carbohydrazides <b>11</b> were designed and synthesized from their corresponding ester intermediates <b>17</b>, which were prepared via cycloaddition of ethyl is...

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Bibliographic Details
Main Authors: Thompho J. Rashamuse, Muhammad Q. Fish, E. Mabel Coyanis, Moira L. Bode
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
ethyl 1,5-diaryl-1<i>H</i>-imidazole-4-carboxylates
1,5-diaryl-1<i>H</i>-imidazole-4-carboxylic acids
1,5-diaryl-1<i>H</i>-imidazole-4-carbohydrazides
ethyl isocyanoacetate
<i>N</i>-aryl-benzimidoyl chlorides
HIV-1 integrase
Online Access:https://www.mdpi.com/1420-3049/26/20/6203

Internet

https://www.mdpi.com/1420-3049/26/20/6203

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