Immune profiling of the progression of a BALB/c mouse aerosol infection by Burkholderia pseudomallei and the therapeutic implications of targeting HMGB1

Introduction: The role of damage-associated molecular pattern HMGB1 signalling in a murine BALB/c model of severe respiratory melioidosis (Burkholderia pseudomallei infection) was explored in this study. Methods: Time course experiments were performed. Results: It was established that HMGB1 was rele...

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Bibliographic Details
Main Authors: Thomas R. Laws, Graeme C. Clark, Riccardo V. D’Elia
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:International Journal of Infectious Diseases
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971215002131