Metformin improves fibroblast metabolism and ameliorates arthrofibrosis in rats

Metformin improves fibroblast metabolism and ameliorates arthrofibrosis in rats

Background: Emerging studies have suggested an essential role of fibroblast metabolic reprogramming in the pathogenesis of arthrofibrosis. The metabolic modulator metformin appears to be a therapeutic candidate for fibrotic disorders. However, whether metformin could alleviate arthrofibrosis has not...

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Bibliographic Details
Main Authors: Zhenglin Zhu, Shengqiang Gao, Hui Zhu, Yi Chen, Dandong Wu, Zhiyu Chen, Yanran Huang, Xiangdong Wu, Ning Hu, Di Chen, Wei Huang, Hong Chen
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Arthrofibrosis
Fibroblast
Glycolysis
Metabolic reprogramming
Metformin
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000384

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http://www.sciencedirect.com/science/article/pii/S2214031X23000384

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