Effect of hydroxyurea on SP1, LIN28B, IGF2BP3, COL4A5, BCL2, gamma globin genes expression: an in vitro study

Effect of hydroxyurea on SP1, LIN28B, IGF2BP3, COL4A5, BCL2, gamma globin genes expression: an in vitro study

Abstract Background In some β-thalassemia intermedia patients, hydroxyurea (HU) increases hemoglobin and HbF levels. However, HUs’ effects molecular mechanism is still unclear. Methods In this study, a weighted gene co-expression network analysis was conducted on the GSE109186 dataset. The genes LIN...

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Bibliographic Details
Main Authors: Akram Agha-Amini Fashami, Esmat Alemzadeh, Hossein Safarpour, Ebrahim Miri-Moghaddam
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Thalassemia
Hemoglobin F
Gene expression
Hydroxyurea
Online Access:https://doi.org/10.1186/s43042-023-00452-8

Internet

https://doi.org/10.1186/s43042-023-00452-8

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