Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside

Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside

Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulations. Thus, we compared the anti-SARS-CoV-2 activity of remdes...

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Bibliographic Details
Main Authors: Sijia Tao, Keivan Zandi, Leda Bassit, Yee Tsuey Ong, Kiran Verma, Peng Liu, Jessica A. Downs-Bowen, Tamara McBrayer, Julia C. LeCher, James J. Kohler, Philip R. Tedbury, Baek Kim, Franck Amblard, Stefan G. Sarafianos, Raymond F. Schinazi
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
COVID-19
Antiviral agents
Coronavirus
Anti-SARS-CoV-2
Remdesivir
GS-441524
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257121000328

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http://www.sciencedirect.com/science/article/pii/S2590257121000328

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