SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

Abstract Background As a consequence of SARS-CoV-2 infection various neurocognitive and neuropsychiatric symptoms can appear, which may persist for several months post infection. However, cell type-specific routes of brain infection and underlying mechanisms resulting in neuroglial dysfunction are n...

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Bibliographic Details
Main Authors: Chiara Stüdle, Hideaki Nishihara, Sven Wischnewski, Laila Kulsvehagen, Sylvain Perriot, Hiroshi Ishikawa, Horst Schroten, Stephan Frank, Nikolaus Deigendesch, Renaud Du Pasquier, Lucas Schirmer, Anne-Katrin Pröbstel, Britta Engelhardt
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Fluids and Barriers of the CNS
Subjects:
SARS-CoV-2
Blood-brain barrier
Blood-cerebrospinal fluid barrier
hiPSC-derived brain microvascular endothelial cells
Choroid plexus epithelial cells
Online Access:https://doi.org/10.1186/s12987-023-00479-4

Internet

https://doi.org/10.1186/s12987-023-00479-4

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