Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1

Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1

Abstract Background Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal disease, esophageal squamous cell carcinoma (ESCC). Methods The expressio...

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Bibliographic Details
Main Authors: Yang Yang, Yuan Zhang, Zongxiang Lin, Kai Wu, Zhanfeng He, Dengyan Zhu, Jia Zhao, Chunyang Zhang, Yuxia Fan
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cancer Cell International
Subjects:
Histone deacetylase 3
Esophageal squamous cell carcinoma
Transforming growth factor beta-inducing factor 1
microRNA-494
Transforming growth factor-β signaling pathway
Online Access:https://doi.org/10.1186/s12935-022-02581-3

Internet

https://doi.org/10.1186/s12935-022-02581-3

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