Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules.

Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules.

Epiplakin, a member of the plakin protein family, is exclusively expressed in epithelial tissues and was shown to bind to keratins. Epiplakin-deficient (EPPK-/-) mice showed no obvious spontaneous phenotype, however, EPPK-/- keratinocytes displayed faster keratin network breakdown in response to str...

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Bibliographic Details
Main Authors: Karl L Wögenstein, Sandra Szabo, Mariia Lunova, Gerhard Wiche, Johannes Haybaeck, Pavel Strnad, Peter Boor, Martin Wagner, Peter Fuchs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0108323

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https://doi.org/10.1371/journal.pone.0108323

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