Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

Schwann Cell-Derived CCL2 Promotes the Perineural Invasion of Cervical Cancer

Perineural invasion (PNI) has guiding significances for nerve preservation in cervical cancer, but there is no definite marker indicating PNI. Two cervical cancer cell lines (HeLa and ME-180) showed significant abilities to migrate along neurites in vitro and in vivo. Morphological observation revea...

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Bibliographic Details
Main Authors: Ting Huang, Qiong Fan, Yiwei Wang, Yunxia Cui, Zhihua Wang, Linlin Yang, Xiao Sun, Yudong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
perineural invasion
Schwann cell
cervical cancer
CCL2/CCR2 axis
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00019/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00019/full

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