Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53

Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53

Abstract Background Recurrence with distant metastases has become the predominant pattern of failure in locally advanced rectal cancer (LARC), thus the integration of new antineoplastic agents into preoperative fluoropyrimidine-based chemo-radiotherapy represents a clinical challenge to implement an...

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Bibliographic Details
Main Authors: Manuela Terranova-Barberio, Biagio Pecori, Maria Serena Roca, Serena Imbimbo, Francesca Bruzzese, Alessandra Leone, Paolo Muto, Paolo Delrio, Antonio Avallone, Alfredo Budillon, Elena Di Gennaro
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
HDAC inhibitor
Valproic acid
Radiotherapy
Colorectal cancer
Capecitabine
p53
Online Access:http://link.springer.com/article/10.1186/s13046-017-0647-5

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http://link.springer.com/article/10.1186/s13046-017-0647-5

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