2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans

2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans

High levels of 2-hydroxyisobutyric acid (2-HIBA) were found in urines of patients with obesity and hepatic steatosis, suggesting a potential involvement of this metabolite in clinical conditions. The gut microbial origin of 2-HIBA was hypothesized, however its actual origin and role in biological pr...

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Bibliographic Details
Main Authors: Emily Schifano, Giorgia Conta, Adele Preziosi, Carino Ferrante, Giovanni Batignani, Patrizia Mancini, Alberta Tomassini, Fabio Sciubba, Tullio Scopigno, Daniela Uccelletti, Alfredo Miccheli
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
2-hydroxyisobutyric acid
Caenorhabditis elegans
ageing
lipid metabolism
oxidative stress
high-glucose diet
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.986022/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.986022/full

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