PCSK9 inhibition and cholesterol homeostasis in insulin producing β-cells

PCSK9 inhibition and cholesterol homeostasis in insulin producing β-cells

Abstract Low-density lipoprotein cholesterol (LDL-C) plays a central role in the pathology of atherosclerotic cardiovascular disease. For decades, the gold standard for LDL-C lowering have been statins, although these drugs carry a moderate risk for the development of new-onset diabetes. The inhibit...

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Bibliographic Details
Main Authors: Günter Päth, Nikolaos Perakakis, Christos S. Mantzoros, Jochen Seufert
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Lipids in Health and Disease
Subjects:
PCSK9 inhibitors
Glucose homeostasis
Insulin secretion
Loss of function gene variants
Knockout models
Pancreatic β-cells
Online Access:https://doi.org/10.1186/s12944-022-01751-6

Internet

https://doi.org/10.1186/s12944-022-01751-6

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