Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts

Dual calcium-voltage optical mapping of regional voltage and calcium signals in intact murine RyR2-R2474S hearts

Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca2+ release, but their underlying mechanism have not been well explored in intact hearts....

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Bibliografische gegevens
Hoofdauteurs: Yangpeng Li, Zhu Liu, Christopher O'Shea, Jianhong Li, Xian Luo, Tangting Chen, Xianhong Ou, Weichao Liu, Guoliang Hao, Christopher L.-H. Huang, Davor Pavlovic, Xiaoqiu Tan, Ming Lei
Formaat: Artikel
Taal:English
Gepubliceerd in: Elsevier 2024-12-01
Reeks:Journal of Molecular and Cellular Cardiology Plus
Onderwerpen:
Catecholaminergic polymorphic ventricular tachycardia
Action potentials
Ca2+ transients
RyR2
Murine cardiac models
Online toegang:http://www.sciencedirect.com/science/article/pii/S2772976124000618

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http://www.sciencedirect.com/science/article/pii/S2772976124000618

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