Tamoxifen Rechallenge Decreases Metastatic Potential but Increases Cell Viability and Clonogenicity in a Tamoxifen-Mediated Cytotoxicity-Resistant Subline of Human Breast MCF7 Cancer Cells

BackgroundDrug resistance is frequently found in estrogen receptor–positive (ER+) breast cancer patients during and after prolonged tamoxifen treatment. Although tamoxifen rechallenge has been proposed for treating recurrent breast tumors, the clinical benefit of this treatment is still controversia...

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Bibliografiska uppgifter
Huvudupphovsmän: Yung-Chieh Chang, Chun Hei Antonio Cheung, Yao-Lung Kuo
Materialtyp: Artikel
Språk:English
Publicerad: Frontiers Media S.A. 2020-06-01
Serie:Frontiers in Cell and Developmental Biology
Ämnen:
Länkar:https://www.frontiersin.org/article/10.3389/fcell.2020.00485/full