Integrative analysis of gut microbiome and host transcriptomes reveals associations between treatment outcomes and immunotherapy‐induced colitis

Integrative analysis of gut microbiome and host transcriptomes reveals associations between treatment outcomes and immunotherapy‐induced colitis

Immune checkpoint inhibitors (ICIs) are widely used to treat various malignancies. Although the gut microbiome is known to influence the efficacy of ICIs on epithelial tumors, the functional interactions between gut taxa and colonic mucosa remain poorly understood. Here we performed transcriptomic p...

Full description

Bibliographic Details
Main Authors: Toshiharu Sakurai, Marco A De Velasco, Kazuko Sakai, Tomoyuki Nagai, Hiroki Nishiyama, Kentaro Hashimoto, Hirotsugu Uemura, Hisato Kawakami, Kazuhiko Nakagawa, Hiroyuki Ogata, Kazuto Nishio, Masatoshi Kudo
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Molecular Oncology
Subjects:
Enterobacteriaceae
gastrointestinal immune‐related adverse event
immune checkpoint
integrative analysis
microbiome
whole transcriptome
Online Access:https://doi.org/10.1002/1878-0261.13062

Internet

https://doi.org/10.1002/1878-0261.13062

Similar Items