The kinetochore prevents centromere-proximal crossover recombination during meiosis

The kinetochore prevents centromere-proximal crossover recombination during meiosis

During meiosis, crossover recombination is essential to link homologous chromosomes and drive faithful chromosome segregation. Crossover recombination is non-random across the genome, and centromere-proximal crossovers are associated with an increased risk of aneuploidy, including Trisomy 21 in huma...

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Bibliographic Details
Main Authors: Nadine Vincenten, Lisa-Marie Kuhl, Isabel Lam, Ashwini Oke, Alastair RW Kerr, Andreas Hochwagen, Jennifer Fung, Scott Keeney, Gerben Vader, Adèle L Marston
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
meiosis
kinetochore
DNA repair
recombination
chromosome segregation
DNA break formation
Online Access:https://elifesciences.org/articles/10850

Internet

https://elifesciences.org/articles/10850

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