miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy

miR-326 overexpression inhibits colorectal cancer cell growth and proteasome activity by targeting PNO1: unveiling a novel therapeutic intervention strategy

Abstract Proteasome inhibition emerges as a promising strategy for cancer prevention. PNO1, pivotal for colorectal cancer (CRC) progression, is involved in proteasome assembly in Saccharomyces cerevisiae. Hence, we aimed to explore the role of PNO1 in proteasome assembly and its up- and down-streams...

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Bibliographic Details
Main Authors: Yi Fang, Yulun Wu, Xinran Zhang, Lihui Wei, Liya Liu, Youqin Chen, Daxin Chen, Nanhui Xu, Liujin Cao, Jie Zhu, Mian Chen, Ying Cheng, Thomas J. Sferra, Mengying Yao, Aling Shen, Jun Peng
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Colorectal cancer
PNO1
MiR-326
Proteasome assembly
P27KIP1
Online Access:https://doi.org/10.1038/s41598-024-75746-x

Internet

https://doi.org/10.1038/s41598-024-75746-x

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