BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H<sub>1</sub> Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins

BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H<sub>1</sub> Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins

The histamine H<sub>1</sub> receptor (H<sub>1</sub>R) is a G protein-coupled receptor (GPCR) and plays a key role in allergic reactions upon activation by histamine which is locally released from mast cells and basophils. Consequently, H<sub>1</sub>R is a well-est...

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Bibliographic Details
Main Authors: Eléonore W. E. Verweij, Reggie Bosma, Meichun Gao, Jelle van den Bor, Betty Al Araaj, Sabrina M. de Munnik, Xiaoyuan Ma, Rob Leurs, Henry F. Vischer
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
histamine
H<sub>1</sub>R
GPCR
G protein
β-arrestin
GPCR kinase
Online Access:https://www.mdpi.com/1422-0067/23/6/3184

Internet

https://www.mdpi.com/1422-0067/23/6/3184

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