A master regulator of cholesterol biosynthesis constitutes a therapeutic liability of triple negative breast cancer

A master regulator of cholesterol biosynthesis constitutes a therapeutic liability of triple negative breast cancer

Lipid and cholesterol reprogramming are often observed in specific cancer subtypes. We find that triple-negative breast cancers (TNBCs), but not estrogen receptor-positive (ER+) ones, adopt nuclear receptor RAR-related orphan receptor γ (RORγ) as their new master activator of cholesterol biosynthesi...

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Bibliographic Details
Main Authors: Demin Cai, Xiong Zhang, Hong-Wu Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2020-03-01
Series:Molecular & Cellular Oncology
Subjects:
tnbc
cholesterol homeostasis
statins
er-positive breast cancer
rorγ
srebp2
chromatin
therapy
Online Access:http://dx.doi.org/10.1080/23723556.2019.1701362

Internet

http://dx.doi.org/10.1080/23723556.2019.1701362

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