An expanded analysis of pharmacogenetics determinants of efavirenz response that includes 3'-UTR single nucleotide polymorphisms among Black South African HIV/AIDS patients

An expanded analysis of pharmacogenetics determinants of efavirenz response that includes 3'-UTR single nucleotide polymorphisms among Black South African HIV/AIDS patients

Introduction: Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor prescribed as part of first-line highly active antiretroviral therapy in South Africa. Despite administration of fixed doses of EFV, inter-individual variability in EFV plasma concentrations has been reported. Poor tre...

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Bibliographic Details
Main Authors: Marelize eSwart, Jonathan eEvans, Michelle eSkelton, sandra ecastel, Lubbe eWeisner, Peter John Smith, Collet eDandara
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Genetics
Subjects:
Pharmacogenetics
Single nucleotide polymorphism
hiv/aids
specificity
Sensitivity
efavirenz
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00356/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00356/full

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