Evaluation of 2-Thioxoimadazolidin-4-one Derivatives as Potent Anti-Cancer Agents through Apoptosis Induction and Antioxidant Activation: In Vitro and In Vivo Approaches

Evaluation of 2-Thioxoimadazolidin-4-one Derivatives as Potent Anti-Cancer Agents through Apoptosis Induction and Antioxidant Activation: In Vitro and In Vivo Approaches

Background: Hepatocellular carcinoma (HCC) is one of the most widespread malignancies and is reported as the fourth most prevalent cause of cancer deaths worldwide. Therefore, we aimed to investigate the probable mechanistic cytotoxic effect of the promising 2-thioxoimidazolidin-4-one derivative on...

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Bibliographic Details
Main Authors: Mohamed S. Nafie, Ahmed I. Khodair, Hebat Allah Y. Hassan, Noha M. Abd El-Fadeal, Hanin A. Bogari, Sameh S. Elhady, Safwat A. Ahmed
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
apoptosis
molecular docking
PI3K/AKT
2-thioxoimadazolidin-4-one
in vivo
antioxidant activity
Online Access:https://www.mdpi.com/1420-3049/27/1/83

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https://www.mdpi.com/1420-3049/27/1/83

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