Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

Abstract Background SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. Hence, SAMHD1 inhibitors are promising candidates for the sen...

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Bibliographic Details
Main Authors: Tamara Rothenburger, Dominique Thomas, Yannick Schreiber, Paul R. Wratil, Tamara Pflantz, Kirsten Knecht, Katie Digianantonio, Joshua Temple, Constanze Schneider, Hanna-Mari Baldauf, Katie-May McLaughlin, Florian Rothweiler, Berna Bilen, Samira Farmand, Denisa Bojkova, Rui Costa, Nerea Ferreirós, Gerd Geisslinger, Thomas Oellerich, Yong Xiong, Oliver T. Keppler, Mark N. Wass, Martin Michaelis, Jindrich Cinatl
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Leukemia
Acute myeloid leukemia
Acute lymphoblastic leukemia
CNDAC
Sapacitabine
SAMHD1
Online Access:https://doi.org/10.1186/s13046-021-02093-4

Internet

https://doi.org/10.1186/s13046-021-02093-4

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