Generation and Characterization of Human-Mouse STING Chimeras That Allow DENV Replication in Mouse Cells

Generation and Characterization of Human-Mouse STING Chimeras That Allow DENV Replication in Mouse Cells

ABSTRACT Our group was the first to describe direct antagonism of the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway by dengue virus (DENV) in human cells, and here, we report new findings on the characterization of the interaction between the DENV nonstructural protei...

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Bibliographic Details
Main Authors: Tongtong Zhu, Laurence G. Webb, Jeury Veloz, Maris Wilkins, Sebastian Aguirre, Ana Fernandez-Sesma
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSphere
Subjects:
dengue
flavivirus
innate immunity
recombinant proteins
viral antagonism
Online Access:https://journals.asm.org/doi/10.1128/msphere.00914-21

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https://journals.asm.org/doi/10.1128/msphere.00914-21

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