Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalation

Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalation

AbstractIn the present study, 5-arylidene rhodanine derivatives 3a–f, N-glucosylation rhodanine 6, S-glucosylation rhodanine 7, N-glucoside rhodanine 8 and S-glucosylation 5-arylidene rhodanines 13a–c were synthesised and screened for cytotoxicity against a panel of cancer cells with investigating t...

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Bibliographic Details
Main Authors: Ahmed I. Khodair, Fatimah M. Alzahrani, Mohamed K. Awad, Siham A. Al-Issa, Ghaferah H. Al-Hazmi, Mohamed S. Nafie
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Thiazolidinones
antitumor activity
apoptosis
molecular modelling
DFT calculations
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2163996

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2163996

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