The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

The molecular chaperone HSP90 is involved in stabilization and function of multiple client proteins, many of which represent important oncogenic drivers in NSCLC. Utilization of HSP90 inhibitors as radiosensitizing agents is a promising approach. The antitumor activity of ganetespib, HSP90 inhibito...

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Bibliographic Details
Main Authors: Roberto Gomez-Casal, Chitralekha Bhattacharya, Michael W. Epperly, Per H. Basse, Hong Wang, Xinhui Wang, David A. Proia, Joel S. Greenberger, Mark A. Socinski, Vera Levina
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Cancers
Subjects:
HSP90 inhibitor ganetespib
lung adenocarcinoma
xenografted tumors
ionizing radiation
senescence
apoptosis
cell cycle
DNA repair
Online Access:http://www.mdpi.com/2072-6694/7/2/0814

Internet

http://www.mdpi.com/2072-6694/7/2/0814

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