IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

Abstract Introduction The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/sIL6R signal is not well characterized. Th...

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Bibliographic Details
Main Authors: Alvaro Valin, Manuel J. Del Rey, Cristina Municio, Alicia Usategui, Marina Romero, Jesús Fernández-Felipe, Juan D. Cañete, Francisco J. Blanco, Yolanda Ruano, Gabriel Criado, José L. Pablos
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Molecular and Cell Biology
Subjects:
IL6
TNFα
Soluble receptor
Synovial fibroblast
Inflammatory response
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s12860-020-00317-7

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http://link.springer.com/article/10.1186/s12860-020-00317-7

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