Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

Mitochondria are highly specialized organelles essential for the synapse, and their impairment contributes to the neurodegeneration in Alzheimer’s disease (AD). Previously, we studied the role of caspase-3–cleaved tau in mitochondrial dysfunction in AD. In neurons, the presence of this AD-relevant t...

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Bibliographic Details
Main Authors: Rodrigo A. Quintanilla, Carola Tapia-Monsalves, Erick H. Vergara, María José Pérez, Alejandra Aranguiz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
kinesin
mitochondria
tau
TRAK2/Milton
transport
truncated tau
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00175/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00175/full

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