The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing

The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing

Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is absolutely required for αβTCR activation. Here, we demonstrate that the CD3 CC is not induced by antigen stimulation of...

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Bibliographic Details
Main Authors: Elaine P. Dopfer, Frederike A. Hartl, Hans-Heinrich Oberg, Gabrielle M. Siegers, O. Sascha Yousefi, Sylvia Kock, Gina J. Fiala, Beatriz Garcillán, Andrew Sandstrom, Balbino Alarcón, Jose R. Regueiro, Dieter Kabelitz, Erin J. Adams, Susana Minguet, Daniela Wesch, Paul Fisch, Wolfgang W.A. Schamel
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003519

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http://www.sciencedirect.com/science/article/pii/S2211124714003519

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