Causal Relationships between Lipid-Lowering Drug Target and Aortic Disease and Calcific Aortic Valve Stenosis: A Two-Sample Mendelian Randomization

Causal Relationships between Lipid-Lowering Drug Target and Aortic Disease and Calcific Aortic Valve Stenosis: A Two-Sample Mendelian Randomization

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), cholesteryl ester transfer protein (CETP) and apolipoprotein C3 (APOC3) are pivotal regulators of lipid metabolism, with licensed drugs targeting these genes. The use of lipid-...

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Bibliographic Details
Main Authors: Liang Yang, Mingyuan Xu, Xixi Gao, Jingwen Liu, Dingkai Zhang, Zhaohua Zhang, Zhidong Ye, Jianyan Wen, Peng Liu
Format: Article
Language:English
Published: IMR Press 2024-08-01
Series:Reviews in Cardiovascular Medicine
Subjects:
mendelian randomization
lipid-lowering drug target
aortic disease
calcific aortic valve stenosis
Online Access:https://www.imrpress.com/journal/RCM/25/8/10.31083/j.rcm2508292

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https://www.imrpress.com/journal/RCM/25/8/10.31083/j.rcm2508292

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