A supernumerary synthetic chromosome in Komagataella phaffii as a repository for extraneous genetic material

A supernumerary synthetic chromosome in Komagataella phaffii as a repository for extraneous genetic material

Abstract Background Komagataella phaffii (Pichia pastoris) is a methylotrophic commercially important non-conventional species of yeast that grows in a fermentor to exceptionally high densities on simple media and secretes recombinant proteins efficiently. Genetic engineering strategies are being ex...

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Bibliographic Details
Main Authors: Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Microbial Cell Factories
Subjects:
Pichia pastoris
Yeast
Biomanufacture
Artificial chromosome
Therapeutic proteins
Complement factor H
Online Access:https://doi.org/10.1186/s12934-023-02262-4

Internet

https://doi.org/10.1186/s12934-023-02262-4

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