Polymorphisms of Cytochromes P450 and Glutathione S-Transferases Synergistically Modulate Risk for Parkinson’s Disease

Polymorphisms of Cytochromes P450 and Glutathione S-Transferases Synergistically Modulate Risk for Parkinson’s Disease

BackgroundEnvironmental substances such as pesticides are well-known in link with Parkinson’s disease (PD) risk. Enzymes including cytochromes P450 (CYPs), esterases and glutathione S-transferases (GSTs) are responsible for the xenobiotic metabolism and may functionally compensate each other for sub...

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Bibliographic Details
Main Authors: Hui-Hui Fan, Bao-Qing Li, Ke-Yun Wu, Hai-Dan Yan, Meng-Jie Gu, Xing-Hao Yao, Hao-Jia Dong, Xiong Zhang, Jian-Hong Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
metabolizing enzymes
Parkinsion’s disease
polymorphism
synergistic effect
genetic association
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.888942/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.888942/full

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