Adjunct Therapy with T Regulatory Cells Decreases Inflammation and Preserves the Anti-Tumor Activity of CAR T Cells

Adjunct Therapy with T Regulatory Cells Decreases Inflammation and Preserves the Anti-Tumor Activity of CAR T Cells

With greater accessibility and an increased number of patients being treated with CAR T cell therapy, real-world toxicity continues to remain a significant challenge to its widespread adoption. We have previously shown that allogeneic umbilical cord blood-derived (UCB) regulatory T cells (Tregs) can...

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Bibliographic Details
Main Authors: Ke Zeng, Meixian Huang, Mi-Ae Lyu, Joseph D. Khoury, Sairah Ahmed, Krina K. Patel, Boro Dropulić, Jane Reese-Koc, Paolo F. Caimi, Tara Sadeghi, Marcos de Lima, Christopher R. Flowers, Simrit Parmar
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
regulatory T cells
CAR T cells
CRS
lymphoma
allogeneic
umbilical cord blood
Online Access:https://www.mdpi.com/2073-4409/12/14/1880

Internet

https://www.mdpi.com/2073-4409/12/14/1880

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