Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

Acetaminophen (N‐acetyl‐para‐aminophenol [APAP]) overdose is the most common cause of drug‐induced liver injury in the Western world and has limited therapeutic options. As an important dietary component intake, fructose is mainly metabolized in liver, but its impact on APAP‐induced liver injury is...

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Bibliographic Details
Main Authors: Deqiang Zhang, Sujuan Wang, Erin Ospina, Omar Shabandri, Daniel Lank, Jephte Y. Akakpo, Zifeng Zhao, Meichan Yang, Jun Wu, Hartmut Jaeschke, Pradip Saha, Xin Tong, Lei Yin
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2021-06-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.1683

Internet

https://doi.org/10.1002/hep4.1683

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