Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization

Abstract No licensed human vaccines are currently available against leishmaniasis. Several anti-leishmanial vaccines are currently undergoing testing, including genetically modified live-attenuated parasite vaccines. Studies with live attenuated Leishmania vaccines such as centrin deleted Leishmania...

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Bibliographic Details
Main Authors: Sreenivas Gannavaram, John Torcivia, Lusine Gasparyan, Amit Kaul, Nevien Ismail, Vahan Simonyan, Hira L. Nakhasi
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05088-4