Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from <i>Thermotoga maritima</i>

Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from <i>Thermotoga maritima</i>

Arginine is one of the most important nutrients of living organisms as it plays a major role in important biological pathways. However, the accumulation of arginine as consequence of metabolic defects causes hyperargininemia, an autosomal recessive disorder. Therefore, the efficient detection of the...

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Bibliographic Details
Main Authors: Giovanni Smaldone, Alessia Ruggiero, Nicole Balasco, Luigi Vitagliano
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
protein scaffolds
argininemia diagnosis
biosensors
crystal structure
protein dissection
protein stability
Online Access:https://www.mdpi.com/1422-0067/21/20/7503

Internet

https://www.mdpi.com/1422-0067/21/20/7503

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