An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer

An EHMT2/NFYA-ALDH2 signaling axis modulates the RAF pathway to regulate paclitaxel resistance in lung cancer

Abstract Background Lung cancer is a kind of malignancy with high morbidity and mortality worldwide. Paclitaxel (PTX) is the main treatment for non-small cell lung cancer (NSCLC), and resistance to PTX seriously affects the survival of patients. However, the underlying mechanism and potential revers...

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Bibliographic Details
Main Authors: Wenjing Wang, Jianmin Wang, Shuai Liu, Yong Ren, Jingyu Wang, Sen Liu, Wei Cui, Lina Jia, Xing Tang, Jingyu Yang, Chunfu Wu, Lihui Wang
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Molecular Cancer
Subjects:
ALDH2
EHMT2
Non-small cell lung cancer
Paclitaxel resistance
RAS/RAF pathway
Online Access:https://doi.org/10.1186/s12943-022-01579-9

Internet

https://doi.org/10.1186/s12943-022-01579-9

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