Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance

Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance

To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from the Goto-Kakizaki (GK) rat model of type 2 diabetes...

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Bibliographic Details
Main Authors: Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
Format: Article
Language:English
Published: The Company of Biologists 2019-07-01
Series:Disease Models & Mechanisms
Subjects:
eQTL
Diabetes mellitus
Goto-Kakizaki rat
SNP
Spontaneously hypertensive rat
Systems genetics
Transcriptome
Online Access:http://dmm.biologists.org/content/12/7/dmm038539

Internet

http://dmm.biologists.org/content/12/7/dmm038539

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