Alcohol-induced inhibition of bone formation and neovascularization contributes to the failure of fracture healing via the miR-19a-3p/FOXF2 axis

Alcohol-induced inhibition of bone formation and neovascularization contributes to the failure of fracture healing via the miR-19a-3p/FOXF2 axis

Aims: Alcoholism is a well-known detrimental factor in fracture healing. However, the underlying mechanism of alcohol-inhibited fracture healing remains poorly understood. Methods: MicroRNA (miR) sequencing was performed on bone mesenchymal stem cells (BMSCs). The effects of alcohol and miR-19a-3p o...

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Bibliographic Details
Main Authors: Daoyu Zhu, Haoyu Fang, Hongping Yu, Pei Liu, Qianhao Yang, Pengbo Luo, Changqing Zhang, Youshui Gao, Yi-Xuan Chen
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2022-06-01
Series:Bone & Joint Research
Subjects:
microrna-19a-3p
forkhead box f2
alcohol
bone fracture
osteogenesis
vascularization
bone fracture healing
bone formation
bmscs
mesenchymal stem cells
endothelial cells
mouse model
vein
luciferase reporter assay
staining
microrna
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.116.BJR-2021-0596.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.116.BJR-2021-0596.R1

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