Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

Abstract Background In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeline as in patients. However, the long and variable,...

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Bibliographic Details
Main Authors: Nastasja Merle, Sabrina Elmshäuser, Florian Strassheimer, Michael Wanzel, Alexander M. König, Julianne Funk, Michelle Neumann, Katharina Kochhan, Frederik Helmprobst, Axel Pagenstecher, Andrea Nist, Marco Mernberger, André Schneider, Thomas Braun, Tilman Borggrefe, Rajkumar Savai, Oleg Timofeev, Thorsten Stiewe
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Molecular Cancer
Subjects:
Autochthonous mouse tumor
Lung cancer
Orthotopic tumor
Luciferase
CRISPR
Adenovirus
Online Access:https://doi.org/10.1186/s12943-022-01661-2

Internet

https://doi.org/10.1186/s12943-022-01661-2

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