+3179G/A Insulin-Like Growth Factor-1 Receptor Polymorphism: A Novel Susceptibility Contributor in Anti-Ro/SSA Positive Patients with Sjögren’s Syndrome: Potential Clinical and Pathogenetic Implications

+3179G/A Insulin-Like Growth Factor-1 Receptor Polymorphism: A Novel Susceptibility Contributor in Anti-Ro/SSA Positive Patients with Sjögren’s Syndrome: Potential Clinical and Pathogenetic Implications

Background: Alterations of the insulin-like growth factor (IGF) pathway along with genetic variations of the IGF1 receptor (IGF1R) gene have been linked to the development of systemic autoimmunity, possibly through apoptosis induction. This study aims to investigate whether genetic variations of the...

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Bibliographic Details
Main Authors: Charalampos Skarlis, Nikolaos Marketos, Adrianos Nezos, Asimina Papanikolaou, Michael Voulgarelis, Michael Koutsilieris, Haralampos M. Moutsopoulos, Clio P. Mavragani
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Journal of Clinical Medicine
Subjects:
Sjögren’s syndrome
insulin growth factor receptor
rs2229765
anti-Ro/SSA
autoimmunity
pyroptosis
Online Access:https://www.mdpi.com/2077-0383/10/17/3960

Internet

https://www.mdpi.com/2077-0383/10/17/3960

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