Heptanoate Improves Compensatory Mechanism of Glucose Homeostasis in Mitochondrial Long-Chain Fatty Acid Oxidation Defect

Heptanoate Improves Compensatory Mechanism of Glucose Homeostasis in Mitochondrial Long-Chain Fatty Acid Oxidation Defect

Defects in mitochondrial fatty acid β-oxidation (FAO) impair metabolic flexibility, which is an essential process for energy homeostasis. Very-long-chain acyl-CoA dehydrogenase (VLCADD; OMIM 609575) deficiency is the most common long-chain mitochondrial FAO disorder presenting with hypoglycemia as a...

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Bibliographic Details
Main Authors: Siti Nurjanah, Albert Gerding, Marcel A. Vieira-Lara, Bernard Evers, Miriam Langelaar-Makkinje, Ute Spiekerkoetter, Barbara M. Bakker, Sara Tucci
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Nutrients
Subjects:
fatty acid oxidation disorder
glycerol
glucose homeostasis
heptanoate
stable isotope
very long-chain acyl-CoA dehydrogenase
Online Access:https://www.mdpi.com/2072-6643/15/21/4689

Internet

https://www.mdpi.com/2072-6643/15/21/4689

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