Synergistic, long-term effects of glutamate dehydrogenase 1 deficiency and mild stress on cognitive function and mPFC gene and miRNA expression

Synergistic, long-term effects of glutamate dehydrogenase 1 deficiency and mild stress on cognitive function and mPFC gene and miRNA expression

Abstract Glutamate abnormalities in the medial prefrontal cortex (mPFC) are associated with cognitive deficits. We previously showed that homozygous deletion of CNS glutamate dehydrogenase 1 (Glud1), a metabolic enzyme critical for glutamate metabolism, leads to schizophrenia-like behavioral abnorma...

Full description

Bibliographic Details
Main Authors: Kfir Asraf, Hiba Zaidan, Baylasan Natoor, Inna Gaisler-Salomon
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02534-y

Internet

https://doi.org/10.1038/s41398-023-02534-y

Similar Items