An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice

An excitatory lateral hypothalamic circuit orchestrating pain behaviors in mice

Understanding how neuronal circuits control nociceptive processing will advance the search for novel analgesics. We use functional imaging to demonstrate that lateral hypothalamic parvalbumin-positive (LHPV) glutamatergic neurons respond to acute thermal stimuli and a persistent inflammatory irritan...

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Bibliographic Details
Main Authors: Justin N Siemian, Miguel A Arenivar, Sarah Sarsfield, Cara B Borja, Lydia J Erbaugh, Andrew L Eagle, Alfred J Robison, Gina Leinninger, Yeka Aponte
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-05-01
Series:eLife
Subjects:
nociception
lateral hypothalamus
calcium imaging
optogenetics
chemogenetics
pain
Online Access:https://elifesciences.org/articles/66446

Internet

https://elifesciences.org/articles/66446

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